An in vitro study with Monte Carlo simulation using the concepts of PK/PD evaluated the synergistic action of meropenem with fosfomycin dosages against P. aeruginosa isolates producing Metallo-ꞵ-Lactamase (MBL), and demonstrated an important favorable potential of these antimicrobials in combination therapy to treat infections caused by the challenged pathogens. Furthermore, the study demonstrated that extended meropenem infusion can only benefit chronic non-dialysis patients and those infected by pathogens with higher minimum inhibitory concentrations (MICs) (less susceptible).
Referência: Albiero J, Mazucheli J, Barros JPDR, Szczerepa MMDA, Nishiyama SAB, Carrara-Marroni FE, Sy S, Fidler M, Sy SKB, Tognim MCB . Antimicrob Agents Chemother. 2019 May 24;63(6):e00126-19. doi: 10.1128/AAC.00126-19.
