The study evaluated the pharmacodynamic action of in vitro synergism followed by Monte Carlo simulation of combined dosages of meropenem, fosfomycin and polymyxin B against extremely resistant Acinetobacter baumannii isolates, and demonstrated that this triple association provides significant synergistic action suggesting a potential therapeutic alternative in the absence of other treatment options.

Referência: Menegucci TC, Albiero J, Migliorini LB, Alves JL, Viana GF, Mazucheli J, Carrara-Marroni FE, Cardoso CL, Tognim MC. Int J Antimicrob Agents. 2016 May;47(5):380-5. doi: 10.1016/j.ijantimicag.2016.02.007.